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Ingredient

Quercetin

Promising

A plant flavonoid of mechanistic interest with a small human-trial record.

How it works

Antioxidant and mast-cell stabilizing activity in vitro; oral bioavailability is low.

Evidence

A 28-day RCT in hypertensives reported blood-pressure reduction at 730 mg/day; a separate dose-ranging study confirmed plasma quercetin rises with daily 50-150 mg dosing.

Studies

Edwards et al., J Nutr, 2007
730 mg quercetin/d for 28 days reduced systolic and diastolic blood pressure in stage 1 hypertensive subjects (n=22).
PubMed 17951477 ↗
Egert et al., J Nutr, 2008
Daily quercetin at 50, 100, or 150 mg for 2 weeks dose-dependently raised plasma quercetin concentrations in 35 healthy volunteers; no effect on antioxidant status, oxidized LDL, inflammation, or metabolism.
PubMed 18716159 ↗

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