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Ingredient

Nicotinamide Mononucleotide (NMN)

Promising

An NAD+ precursor of significant lab-scale interest; human RCT evidence is still emerging.

How it works

Enters cells and contributes to NAD+ pool; the human pharmacokinetic and clinical record is still developing.

Evidence

A 60-day dose-ranging RCT in 80 healthy middle-aged adults compared NMN at 300/600/900 mg/day; all doses significantly raised blood NAD versus placebo, with peak benefit at 600 mg/day.

Studies

Yi et al., GeroScience, 2023
Once-daily NMN at 300, 600, or 900 mg for 60 days significantly increased blood NAD versus placebo (all p ≤ 0.001) and improved 6-minute walking distance; effects were highest at 600-900 mg.
PubMed 36482258 ↗

One ingredient, one study, one product worth your money.

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