This site provides general information only and is not medical advice. Talk to a qualified healthcare professional before starting any supplement, especially if you are pregnant, take prescription medication, or have a medical condition.

Some links on this page are affiliate links. If you buy through them, we earn a commission at no extra cost to you. It does not change which products we recommend — see our methodology and full disclosure.

Ingredient

Niacinamide (Nicotinamide)

Promising

An NAD+ precursor and B-vitamin form with a long human-use record.

How it works

Converts to NAD+ via the salvage pathway and supports cellular redox metabolism.

Evidence

The ONTRAC phase-3 RCT showed 500 mg nicotinamide twice daily for 12 months reduced new non-melanoma skin cancers in high-risk adults; broader anti-aging or NAD-restoration claims are not directly supported by this trial.

Studies

Chen et al., N Engl J Med, 2015 (ONTRAC trial)
500 mg of nicotinamide twice daily for 12 months reduced new non-melanoma skin cancers by 23% versus placebo in 386 high-risk adults; well tolerated.
PubMed 26488693 ↗

One ingredient, one study, one product worth your money.

Weekly. No fluff. Unsubscribe in one click.